Entry into a Material Definitive Agreement.

On March 16, 2026, Elicio Therapeutics, Inc. (the "Company") entered into an At Market Issuance Sales Agreement (the "Sales Agreement") with B. Riley Securities, Inc., JonesTrading Institutional Services LLC and Ladenburg Thalmann & Co. Inc. (the "Agents") with respect to an at-the-market offering program under which the Company may issue and sell, from time to time at its sole discretion, shares of its common stock, par value $0.01 per share (the "Common Stock"), having an aggregate offering price of up to $100.0 million (the "Placement Shares") through the Agents. The issuance and sale, if any, of the Placement Shares by the Company under the Sales Agreement will be made pursuant to the Company's registration statement on Form S-3 (File No. 333-293861), as amended.

Upon delivery of a placement notice and subject to the terms and conditions of the Sales Agreement, the Agents may sell the Placement Shares by any method permitted by law deemed to be an "at the market" offering as defined in Rule 415 of the Securities Act of 1933, as amended, including, without limitation, sales made through The Nasdaq Capital Market or on any other existing trading market for the Common Stock. The Agents will use commercially reasonable efforts to sell the Placement Shares from time to time, based upon instructions from the Company (including any price, time or size limits or other customary parameters or conditions the Company may impose). The Company will pay the Agents a commission equal to an aggregate of three percent (3.0%) of the gross sales proceeds of any Placement Shares sold through the Agents under the Sales Agreement, and also has provided the Agents with customary indemnification and contribution rights.

The Company is not obligated to make any sales of Common Stock under the Sales Agreement. The offering of Placement Shares pursuant to the Sales Agreement will terminate upon the earlier of (i) the issuance and sale of all Placement Shares subject to the Sales Agreement or (ii) termination of the Sales Agreement in accordance with its terms. The Company may terminate the Sales Agreement at any time upon three days' prior notice and the Agents may terminate the Sales Agreement with respect to itself at any time upon three days' prior notice or immediately upon notice upon the occurrence of certain specified events.

The foregoing description of the Sales Agreement is qualified in its entirety by reference to the full text of the Sales Agreement, which is attached as Exhibit 10.1 hereto and incorporated by reference herein.

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Company, has issued a legal opinion relating to the Placement Shares. A copy of such legal opinion, including the consent included therein, is attached as Exhibit 5.1 hereto.

This Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy the securities discussed herein, nor shall there be any offer, solicitation, or sale of the securities in any state in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state.

Item 1.02 Termination of a Material Definitive Agreement.

As previously disclosed on June 3, 2024, the Company entered into a Capital on Demand™ Sales Agreement with JonesTrading Institutional Services LLC ("Jones") as sales agent (the "Jones Sales Agreement"), pursuant to which the Company was permitted to issue and sell, from time to time through Jones, shares of the Company's common stock having an aggregate offering price of up to $40.0 million.

On March 16, 2026, the Company delivered written notice to Jones to terminate the Jones Sales Agreement and the offering of shares contemplated thereby, effective upon delivery, pursuant to Section 12(b) of the Jones Sales Agreement. Jones waived the Company's requirement in Section 12(b) of the Jones Sales Agreement to provide three (3) days' written notice to terminate the Jones Sales Agreement and the requirement of Section 12(f) of the Jones Sales Agreement that any termination of the Jones Sales Agreement in accordance with Section 12(b) shall not be effective until ten (10) days after the date of such notice. The Company is not subject to any termination penalties related to the termination of the Jones Sales Agreement.

Following the termination of the Jones Sales Agreement, the Company may not issue or sell any additional shares of its common stock under the Jones Sales Agreement or the related prospectus, effective as of June 11, 2024.

The foregoing description of the Jones Sales Agreement is not complete and is qualified in its entirety by reference to the full text of the Jones Sales Agreement, a copy of which was filed as Exhibit 1.3 to the Company's shelf registration statement on Form S-3 filed with the SEC on June 3, 2024 and declared effective by the SEC on June 11, 2024, and of which is incorporated herein by reference.