Picard Medical, Inc. (NYSE:PMI) (the "Company"), parent company of SynCardia Systems LLC, maker of the world's first total artificial heart approved by both the U.S. FDA and Health Canada, today announced that a 29-year-old patient successfully received a donor heart transplant after living for more than four years supported entirely by the SynCardia Total Artificial Heart.

The patient was implanted with the SynCardia Total Artificial Heart on September 2, 2021, after developing severe biventricular heart failure. The device replaced the pumping function of both sides of the heart, maintaining circulation while the patient awaited a donor organ. After 1,636 days of continuous artificial heart support, the patient underwent a successful heart transplant on February 24, 2026.

"The challenge in advanced heart failure is often the time required to find a suitable donor organ," said Patrick NJ Schnegelsberg, Chief Executive Officer of Picard Medical. "This case demonstrates how the SynCardia Total Artificial Heart can sustain critically ill patients for extended periods, allowing them to live at home while awaiting heart transplantation."

Total artificial heart therapy is indicated as a bridge to transplant for patients with irreversible biventricular heart failure who cannot be supported with isolated left ventricular assist device therapy. By replacing both ventricles and all four native heart valves, the SynCardia Total Artificial Heart restores circulation and hemodynamic stability while patients await donor organ availability.

More than 2,100 SynCardia Total Artificial Heart implants have been performed worldwide in patients with advanced biventricular heart failure, with the longest documented patient support exceeding eight years on device.

While individual outcomes may vary, extended duration support cases continue to inform clinical practice and illustrate the potential for long term mechanical circulatory support in carefully selected patients.