The allowed claims of the patent protect the RenovoCath dual-occlusion catheter-based system equipped with integrated imaging and pressure-sensing technology that is designed to enable targeted localization and controlled infusion of drugs or biologics into targeted tissue via the vasa vasorum. The vasa vasorum are microscopic blood vessels that supply nutrients and oxygen to the walls of large arteries and provide access to the tissue outside the blood vessels. The ability to target therapeutic agents at this local level is a key attribute of RenovoCath; avoiding systemic dosing of therapeutics, such as intravenous (IV) chemotherapy, which can have debilitating side effects.