Zai Lab reported promising preliminary data from an ongoing registration-enabling multicenter, Phase 1b/2 clinical trial of zoci (NCT06885281) in patients with epNEC and other selected solid tumors at the American Association for Cancer Research (AACR) Annual Meeting 2026 last month. In heavily pretreated patients enrolled in the Phase 1b/2 study, zoci demonstrated encouraging antitumor activity, including an objective response rate(ORR) of 38.2%. Zoci also demonstrated a manageable safety profile—neutrophil count decrease was the only grade ≥3 treatment-related adverse event occurring in more than one patient.

Zai Lab received Fast Track designation for zoci for the treatment of extensive-stage small cell lung cancer (ES-SCLC) in May 2025. Fast Track designation facilitates the expedited development and review of new drugs to address an unmet medical need or treat serious or life-threatening diseases. Benefits of this designation include more frequent engagements with the FDA to discuss the drug's clinical development plan and eligibility for Accelerated Approval and Priority Review if relevant criteria are met.