MannKind Corporation (NASDAQ:MNKD), a biopharmaceutical company focused on developing innovative, patient-centric therapies for chronic diseases, today announced key clinical execution milestones in the development of nintedanib DPI for idiopathic pulmonary fibrosis (IPF), including the completion of patient randomization in the U.S. Phase 1b INFLO-1 clinical trial and enrollment of the first patient in the global Phase 2 INFLO-2 study. These milestones mark the advancement of the nintedanib DPI program and support its progression into mid-stage clinical evaluation.

Positioning for Continued Clinical Development in IPF

MannKind expects to report data from the INFLO-1 study in the third quarter of 2026, which is expected to provide an initial clinical assessment of safety, tolerability, and pharmacokinetics in patients with IPF. INFLO-2 is expected to enroll approximately 210 participants across approximately 85 sites worldwide. The first patient was enrolled in Windsor, Canada.

"We are encouraged by the emerging data from our Phase 1b study, which continues to support our hypothesis around the safety and tolerability of inhaled nintedanib DPI," added Wassim Fares, M.D., MSc, FCCP, Senior Vice President, Therapeutic Area Head – Respiratory. "These findings reinforce the potential of nintedanib DPI as a simple and convenient administration to efficiently deliver therapy directly to the lungs, with potential to maintain antifibrotic effect and improve tolerability and long-term adherence. It may also facilitate the opportunity for use in combination with current and future IPF therapies."

Differentiated Approach to a Significant Unmet Need

IPF is a chronic, progressive lung disease characterized by irreversible fibrosis and declining lung function. Despite available therapies, the disease remains associated with substantial morbidity and mortality.

Nintedanib, currently approved as an oral therapy for IPF, has demonstrated the ability to slow disease progression but can be associated with systemic side effects that may limit tolerability, treatment persistence, and the ability to use combination therapies. Nintedanib DPI (MNKD-201) leverages MannKind's Technosphere® dry powder inhalation technology to deliver nintedanib directly to the deep lung, with the goal of achieving therapeutic concentrations at the site of disease while reducing systemic exposure. MannKind has developed two FDA-approved dry powder inhalation therapies utilizing its proven Technosphere formulation technology, with clinical data demonstrating less than 3% discontinuation due to cough.

"Advancing into this next stage of development represents an important inflection point for our nintedanib DPI program," said Michael Castagna, PharmD, Chief Executive Officer of MannKind Corporation. "With Phase 1b data expected in Q3 2026 and a global Phase 2 study now underway, we believe we are well-positioned to generate early clinical validation of our inhaled approach and to further define its potential in IPF."