— 26 Abstracts Accepted Demonstrate Alkermes' Commitment to Advancing Understanding and Treatment of Narcolepsy and Idiopathic Hypersomnia —

— Detailed Positive Results from Vibrance-2 Phase 2 Study of Alixorexton, an Orexin 2 Receptor Agonist, in Patients With Narcolepsy Type 2 to be Shared in Oral Presentation —

Alkermes plc (NASDAQ:ALKS) today announced plans to present new data from its industry-leading portfolio of sleep medicine research at SLEEP 2026, the 40th annual meeting of the Associated Professional Sleep Societies (APSS), taking place June 14-17, 2026 in Baltimore, MD. The company will present 26 abstracts, including posters featuring LUMRYZ® (sodium oxybate) extended-release oral suspension, now part of Alkermes' sleep portfolio following the acquisition of Avadel Pharmaceuticals plc in February 2026, and alixorexton, Alkermes' novel, investigational, oral, selective orexin 2 receptor (OX2R) agonist in development for narcolepsy type 1 (NT1), narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH).

The company will present detailed results from the alixorexton Vibrance-2 study, the first large phase 2 clinical trial to demonstrate positive results with an OX2R agonist in patients with NT2 (n=93). The data will be shared in an oral presentation by Richard Bogan, M.D., FCCP, FAASM, Principal of Bogan Sleep Consultants, LLC and Associate Clinical Professor at the University of South Carolina School of Medicine. Primary and secondary efficacy and safety data, and exploratory patient-reported outcomes related to fatigue and cognition from the eight-week randomized, double-blind treatment period and optional five-week open-label extension, will be presented.

Abstracts accepted for late-breaking poster presentations include:

  • Baseline characteristics from the phase 3 REVITALYZSM study evaluating the investigational use of LUMRYZ in adults with IH, for which positive topline results were recently announced; and
  • Two posters detailing the study designs and methods for the Brilliance Studies, a phase 3 clinical trial program evaluating the safety and efficacy of alixorexton compared to placebo in patients with NT1 and NT2.