Company to share additional CLYM116 clinical data and plans for further development at R&D Spotlight in late summer

Initiation of CLYM116 dosing in IgAN patients in Mabworks Phase 2 study expected in Q3 2026

WELLESLEY HILLS, Mass., June 05, 2026 (GLOBE NEWSWIRE) -- Climb Bio, Inc. (NASDAQ:CLYM), a clinical stage biotechnology company developing therapeutics for patients with immune-mediated diseases, today announced translational pharmacometric modeling and initial Phase 1 safety data for CLYM116, its anti-APRIL monoclonal antibody. Clinical data demonstrated a favorable initial safety profile, supporting continued development of CLYM116 in IgA nephropathy (IgAN). These data will be presented today as an oral session at the European Renal Association (ERA) Congress 2026, which is being held June 3-6, 2026, in Glasgow, Scotland.

The Company also announced that it plans to share initial pharmacokinetic and pharmacodynamic (PK/PD) data, as well as updated safety data from the ongoing Phase 1 studies of CLYM116 in healthy volunteers, at the next installment of its R&D Spotlight Series, expected to take place in late summer.

Based on the interim data from ongoing Phase 1 studies in healthy volunteers, CLYM116 has been generally well tolerated with no unexpected safety findings. These clinical data include results from a Phase 1 study being conducted by Climb Bio in Australia, and a parallel ongoing Phase 1 study being conducted by the Company's partner, Beijing Mabworks Biotech (Mabworks), in China. With the safety profile observed to date and supportive preclinical data, the Company plans to continue to advance CLYM116 into further clinical development, and Mabworks expects to initiate dosing in IgAN patients in the Phase 2 portion of its ongoing study in the third quarter of 2026. Climb Bio maintains global rights to CLYM116 outside of Greater China.