Jaguar Health, Inc. (NASDAQ:JAGX) ("Jaguar") today announced that the results of a preclinical study initiated by Magdalena Biosciences ("Magdalena"), a US-based joint venture formed by Jaguar and Canada-based Filament Health Corp. ("Filament"), demonstrate that a novel extract derived from leaves of the coca plant prevented weight gain in mice submitted to a high fat diet without reducing food intake or increasing physical activity. The coca leaf extract under evaluation is Magdalena's prescription drug candidate for post-GLP-1 weight loss management, intended for development under the U.S. Food and Drug Administration's Botanical Guidance.

It is common for people to regain weight after stopping GLP-1 medications because these drugs help reduce appetite and increase feelings of fullness while they are being taken. When treatment is discontinued, these effects diminish, and the body's mechanisms that regulate hunger and body weight may promote weight gain.