U.S. stocks were lower, with the Nasdaq Composite falling over 100 points on Wednesday.

Shares of TriSalus Life Sciences Inc (NASDAQ:TLSI) rose sharply after the company announced it received FDA 510(k) clearance for TriNav Advance.

TriSalus Life Sciences shares jumped 5.8% to $5.22 on Wednesday.

Here are some other big stocks recording gains in today’s session.

  • Securitize Corp (NYSE:SECZ) shares jumped 8.1% to $14.04.
  • Lakefront Biotherapeutics NV – ADR (NASDAQ:LKFT) gained 6.8% to $32.24. RBC Capital analyst Brian Abrahams upgraded Lakefront Biotherapeutics from Sector Perform to Outperform and raised the price target from $26 to $45.
  • Bandwidth Inc (NASDAQ:BAND) gained 6.4% to $62.18.
  • Maze Therapeutics Inc (NASDAQ:MAZE) surged 4.6% to $29.68. Wedbush analyst Laura Chico reiterated Maze Therapeutics with an Outperform rating and maintained a $48 price target.
  • Moderna Inc (NASDAQ:MRNA) rose 4.4% to $190.59. The company recently announced three abstracts on its mRNA-based individualized neoantigen therapy intismeran autogene have been accepted for presentation at the ESMO Congress 2026.
  • Editas Medicine Inc (NASDAQ:EDIT) rose 4% to $3.04. Guggenheim analyst Debjit Chattopadhyay upgraded Editas Medicine from Neutral to Buy and announced a $5 price target.
  • Xeris Biopharma Holdings Inc (NASDAQ:XERS) gained 3.4% to $9.03.
  • Palantir Technologies Inc (NASDAQ:PLTR) gained 3.3% to $191.00.
  • Pulse Biosciences Inc (NASDAQ:PLSE) gained 3% to $54.26. BTIG analyst Marie Thibault initiated coverage on Pulse Biosciences with a Buy rating and announced a PRICE TARGEt of $70.

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