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Frazier Life Sciences Management, L.P.
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $4,592,076,814
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- MIRUM PHARMACEUTICALS INC · COM · 604749101 · shares: $899,060,606
- NEWAMSTERDAM PHARMA COMPANY · ORDINARY SHARES · N62509109 · shares: $613,032,889
- ERASCA INC · COM · 29479A108 · shares: $457,545,444
- MBX BIOSCIENCES INC · COM · 55287L101 · shares: $367,191,118
- ARCUTIS BIOTHERAPEUTICS INC · COM · 03969K108 · shares: $258,909,678
- TREVI THERAPEUTICS INC · COM · 89532M101 · shares: $185,370,687
- KRYSTAL BIOTECH INC · COM · 501147102 · shares: $178,887,373
- MAZE THERAPEUTICS INC · COM · 578784100 · shares: $150,182,184
- PHATHOM PHARMACEUTICALS INC · COM · 71722W107 · shares: $135,261,406
- PALVELLA THERAPEUTICS INC NE · COM · 697947109 · shares: $134,848,368
Reported holdings
41 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | — | 7,679,684 shares | $899,060,606 |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | — | 18,088,902 shares | $613,032,889 |
| ERASCA INC | COM | 29479A108 | — | 24,975,188 shares | $457,545,444 |
| MBX BIOSCIENCES INC | COM | 55287L101 | — | 6,652,013 shares | $367,191,118 |
| ARCUTIS BIOTHERAPEUTICS INC | COM | 03969K108 | — | 9,874,511 shares | $258,909,678 |
| TREVI THERAPEUTICS INC | COM | 89532M101 | — | 9,939,447 shares | $185,370,687 |
| KRYSTAL BIOTECH INC | COM | 501147102 | — | 481,307 shares | $178,887,373 |
| MAZE THERAPEUTICS INC | COM | 578784100 | — | 5,032,915 shares | $150,182,184 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | — | 12,466,489 shares | $135,261,406 |
| PALVELLA THERAPEUTICS INC NE | COM | 697947109 | — | 882,400 shares | $134,848,368 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | — | 1,548,139 shares | $115,305,393 |
| DISC MEDICINE INC | COM | 254604101 | — | 1,354,852 shares | $99,093,875 |
| CYTOKINETICS INC | COM NEW | 23282W605 | — | 1,159,879 shares | $98,810,092 |
| DYNE THERAPEUTICS INC | COM | 26818M108 | — | 3,153,082 shares | $70,029,951 |
| ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | — | 225,155 shares | $60,053,342 |
| SAVARA INC | COM | 805111101 | — | 9,720,852 shares | $59,880,448 |
| PARABILIS MEDICINES INC | COM | 698955101 | — | 1,920,805 shares | $52,572,433 |
| AURA BIOSCIENCES INC | COM | 05153U107 | — | 7,100,000 shares | $50,410,000 |
| ACHIEVE LIFE SCIENCE INC | COM | 004468500 | — | 7,614,836 shares | $49,724,879 |
| VOR BIOPHARMA INC | COM NEW | 929033207 | — | 2,543,939 shares | $46,833,917 |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | — | 22,446,668 shares | $46,689,069 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | — | 728,644 shares | $45,860,853 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | — | 4,009,240 shares | $40,092,400 |
| ALKERMES PLC | SHS | G01767105 | — | 700,647 shares | $36,710,400 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | — | 1,438,198 shares | $36,386,409 |
| ZAI LAB LTD | ADR | 98887Q104 | — | 1,902,320 shares | $36,144,080 |
| MANNKIND CORP | COM NEW | 56400P706 | — | 6,600,000 shares | $28,116,000 |
| DESIGN THERAPEUTICS INC | COM | 25056L103 | — | 1,809,854 shares | $26,188,587 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | — | 4,925,374 shares | $26,055,228 |
| SHATTUCK LABS INC | COM | 82024L103 | — | 3,750,000 shares | $26,025,000 |
| KAILERA THERAPEUTICS INC | COMMON STOCK | 482931102 | — | 1,100,000 shares | $24,233,000 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | — | 1,000,000 shares | $24,200,000 |
| LEXEO THERAPEUTICS INC | COM | 52886X107 | — | 4,824,725 shares | $22,459,095 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | — | 1,015,693 shares | $19,003,616 |
| EVOLUS INC | COM | 30052C107 | — | 2,630,665 shares | $18,256,815 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 | — | 484,782 shares | $15,391,829 |
| VALNEVA SE | SPONSORED ADS | 92025Y103 | — | 2,291,666 shares | $11,985,413 |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 99/99/999 | N62509117 | — | 500,333 shares | $10,692,116 |
| AUTOLUS THERAPEUTICS LTD | SPON ADS | 05280R100 | — | 4,447,910 shares | $7,116,656 |
| XILIO THERAPEUTICS INC | COM | 98422T209 | — | 422,505 shares | $4,047,598 |
| IBIO INC | COM NEW | 451033708 | — | 1,953,467 shares | $3,418,567 |