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Opaleye Management Inc.
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $1,104,182,260
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- LIQUIDIA CORPORATION · COM NEW · 53635D202 · shares: $195,139,175
- ETON PHARMACEUTICALS INC · COM · 29772L108 · shares: $103,532,000
- HARROW INC · COM · 415858109 · shares: $101,928,000
- DISC MEDICINE INC · COM · 254604101 · shares: $62,534,700
- UROGEN PHARMA LTD · COM · M96088105 · shares: $52,991,853
- APOGEE THERAPEUTICS INC · COM · 03770N101 · shares: $51,764,700
- MEIRAGTX HLDGS PLC · COM · G59665102 · shares: $47,960,500
- SOL-GEL TECHNOLOGIES LTD · SHS NEW · M8694L137 · shares: $37,070,000
- REZOLUTE INC · COM NEW · 76200L309 · shares: $32,760,000
- TG THERAPEUTICS INC · COM · 88322Q108 · shares: $29,392,900
Reported holdings
58 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| LIQUIDIA CORPORATION | COM NEW | 53635D202 | — | 2,447,500 shares | $195,139,175 |
| ETON PHARMACEUTICALS INC | COM | 29772L108 | — | 2,860,000 shares | $103,532,000 |
| HARROW INC | COM | 415858109 | — | 2,400,000 shares | $101,928,000 |
| DISC MEDICINE INC | COM | 254604101 | — | 855,000 shares | $62,534,700 |
| UROGEN PHARMA LTD | COM | M96088105 | — | 1,439,996 shares | $52,991,853 |
| APOGEE THERAPEUTICS INC | COM | 03770N101 | — | 390,000 shares | $51,764,700 |
| MEIRAGTX HLDGS PLC | COM | G59665102 | — | 3,550,000 shares | $47,960,500 |
| SOL-GEL TECHNOLOGIES LTD | SHS NEW | M8694L137 | — | 500,000 shares | $37,070,000 |
| REZOLUTE INC | COM NEW | 76200L309 | — | 6,300,000 shares | $32,760,000 |
| TG THERAPEUTICS INC | COM | 88322Q108 | — | 535,000 shares | $29,392,900 |
| IMMIX BIOPHARMA INC | COM | 45258H106 | — | 2,345,000 shares | $24,176,950 |
| CRESCENT BIOPHARMA INC. | COM | G2545C104 | — | 1,319,351 shares | $23,748,318 |
| STOKE THERAPEUTICS INC | COM | 86150R107 | — | 700,000 shares | $22,904,000 |
| ALPHA COGNITION INC | COM NEW | 02074J501 | — | 2,895,467 shares | $20,905,272 |
| EDGEWISE THERAPEUTICS INC | COM | 28036F105 | — | 500,000 shares | $20,315,000 |
| REVOLUTION MEDICINES INC | COM | 76155X100 | — | 100,000 shares | $18,728,000 |
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | — | 745,000 shares | $18,029,000 |
| ALUMIS INC | COM | 022307102 | — | 550,000 shares | $15,477,000 |
| CODEXIS INC | COM | 192005106 | — | 6,785,000 shares | $15,334,100 |
| REPLIMUNE GROUP INC | COM | 76029N106 | — | 1,384,993 shares | $15,331,873 |
| XOMA ROYALTY CORPORATION | COM NEW | 98419J206 | — | 338,374 shares | $14,380,895 |
| MBX BIOSCIENCES INC | COM | 55287L101 | — | 260,000 shares | $14,352,000 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | — | 122,500 shares | $13,601,175 |
| EDITAS MEDICINE INC | COM | 28106W103 | — | 3,861,930 shares | $12,512,653 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | — | 100,000 shares | $12,258,000 |
| CABALETTA BIO INC | COM | 12674W109 | — | 3,863,800 shares | $12,016,418 |
| Q32 BIO INC | COM | 746964105 | — | 931,000 shares | $11,860,940 |
| ANNEXON INC | COM | 03589W102 | — | 1,714,451 shares | $9,789,515 |
| VERASTEM INC | COM NEW | 92337C203 | — | 1,800,000 shares | $6,876,000 |
| ZENTALIS PHARMACEUTICALS INC | COM | 98943L107 | — | 1,412,656 shares | $6,851,382 |
| RELMADA THERAPEUTICS INC | COM | 75955J402 | — | 935,000 shares | $6,470,200 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 | — | 600,000 shares | $5,892,000 |
| TREVI THERAPEUTICS INC | COM | 89532M101 | — | 310,000 shares | $5,781,500 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 | — | 700,000 shares | $5,334,000 |
| LYELL IMMUNOPHARMA INC | COM NEW | 55083R203 | — | 344,025 shares | $4,833,551 |
| OPUS GENETICS INC | COM | 67577R102 | — | 1,125,000 shares | $4,623,750 |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | — | 334,437 shares | $4,448,012 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 | — | 250,000 shares | $4,230,000 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | — | 1,185,000 shares | $4,147,500 |
| BIODESIX INC | COM | 09075X207 | — | 180,000 shares | $4,059,000 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | — | 1,000,000 shares | $3,420,000 |
| JADE BIOSCIENCES INC | COM NEW | 008064206 | — | 145,000 shares | $3,221,900 |
| SANUWAVE HEALTH INC | COM | 80303D305 | — | 306,140 shares | $3,061,400 |
| FORTRESS BIOTECH INC | COM NEW | 34960Q307 | — | 890,000 shares | $2,723,400 |
| JOURNEY MED CORP | COM | 48115J109 | — | 350,000 shares | $2,478,000 |
| PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | — | 185,589 shares | $2,013,641 |
| INHIBRX BIOSCIENCES INC | COM | 45720N103 | — | 20,291 shares | $1,922,572 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 | — | 125,000 shares | $1,822,500 |
| HEMAB THERAPEUTICS HLDGS INC | COM SHS | 423494103 | — | 47,652 shares | $1,750,258 |
| FIRST TRACKS BIOTHERAPEUTICS | ORD SHS | 337185102 | — | 65,000 shares | $1,307,800 |
| CG ONCOLOGY INC | COM | 156944100 | — | 17,789 shares | $1,263,908 |
| BIOHAVEN LTD | COM | G1110E107 | — | 77,915 shares | $1,159,375 |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 | — | 235,000 shares | $1,092,750 |
| PASITHEA THERAPEUTICS CORP | COM NEW | 70261F202 | — | 2,050,000 shares | $1,056,570 |
| ADC THERAPEUTICS SA | SHS | H0036K147 | — | 700,000 shares | $749,000 |
| OKYO PHARMA LTD | SHS NEW | G6724L116 | — | 375,204 shares | $562,806 |
| PALATIN TECHNOLOGIES INC | COM NEW | 696077601 | — | 20,500 shares | $221,195 |
| ADAGIO MED HLDGS INC | COM | 00534B100 | — | 18,444 shares | $13,353 |