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RA CAPITAL MANAGEMENT, L.P.
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $11,507,522,068
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- ASCENDIS PHARMA A/S · Common Stock · K08588103 · shares: $2,742,280,613
- PARABILIS MEDICINES INC · Common Stock · 698955101 · shares: $791,906,364
- RHYTHM PHARMACEUTICALS INC · Common Stock · 76243J105 · shares: $740,218,912
- VAXCYTE INC · Common Stock · 92243G108 · shares: $667,018,440
- SIONNA THERAPEUTICS INC · Common Stock · 829401108 · shares: $435,722,930
- TYRA BIOSCIENCES INC · Common Stock · 90240B106 · shares: $389,624,083
- EDGEWISE THERAPEUTICS INC · Common Stock · 28036F105 · shares: $340,996,620
- NEWAMSTERDAM PHARMA CO NV · Common Stock · N62509109 · shares: $323,655,973
- HEMAB THERAPEUTICS HOLDINGS · Common Stock · 423494103 · shares: $286,810,870
- SEPTERNA INC · Common Stock · 81734D104 · shares: $234,291,284
Reported holdings
85 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S | Common Stock | K08588103 | — | 10,281,496 shares | $2,742,280,613 |
| PARABILIS MEDICINES INC | Common Stock | 698955101 | — | 28,933,371 shares | $791,906,364 |
| RHYTHM PHARMACEUTICALS INC | Common Stock | 76243J105 | — | 6,666,837 shares | $740,218,912 |
| VAXCYTE INC | Common Stock | 92243G108 | — | 11,474,599 shares | $667,018,440 |
| SIONNA THERAPEUTICS INC | Common Stock | 829401108 | — | 9,905,045 shares | $435,722,930 |
| TYRA BIOSCIENCES INC | Common Stock | 90240B106 | — | 12,198,625 shares | $389,624,083 |
| EDGEWISE THERAPEUTICS INC | Common Stock | 28036F105 | — | 8,392,730 shares | $340,996,620 |
| NEWAMSTERDAM PHARMA CO NV | Common Stock | N62509109 | — | 9,550,191 shares | $323,655,973 |
| HEMAB THERAPEUTICS HOLDINGS | Common Stock | 423494103 | — | 7,808,627 shares | $286,810,870 |
| SEPTERNA INC | Common Stock | 81734D104 | — | 6,995,858 shares | $234,291,284 |
| BICARA THERAPEUTICS INC | Common Stock | 055477103 | — | 7,255,993 shares | $215,430,432 |
| MINERALYS THERAPEUTICS INC | Common Stock | 603170101 | — | 7,692,750 shares | $207,550,395 |
| GH RESEARCH PLC | Common Stock | G3855L106 | — | 7,636,813 shares | $205,277,533 |
| DISC MEDICINE INC | Common Stock | 254604101 | — | 2,450,221 shares | $179,209,164 |
| SPYGLASS PHARMA INC | Common Stock | 85220G109 | — | 8,021,117 shares | $178,550,064 |
| ARTIVA BIOTHERAPEUTICS INC | Common Stock | 04317A107 | — | 17,955,642 shares | $174,169,727 |
| JANUX THERAPEUTICS INC | Common Stock | 47103J105 | — | 11,189,693 shares | $171,873,684 |
| TAYSHA GENE THERAPIES INC | Common Stock | 877619106 | — | 23,555,648 shares | $160,413,963 |
| BIOCRYST PHARMACEUTICALS INC | Common Stock | 09058V103 | — | 15,827,186 shares | $158,271,860 |
| WAVE LIFE SCIENCES LTD | Common Stock | Y95308105 | — | 26,975,505 shares | $156,727,684 |
| NUVALENT INC-A | Common Stock | 670703107 | — | 1,246,456 shares | $153,937,316 |
| ABIVAX SA-ADR | ADR | 00370M103 | — | 1,132,557 shares | $150,924,546 |
| ORUKA THERAPEUTICS INC | Common Stock | 687604108 | — | 1,554,597 shares | $147,950,996 |
| SOLID BIOSCIENCES INC | Common Stock | 83422E204 | — | 12,036,126 shares | $120,240,899 |
| CLIMB BIO INC | Common Stock | 28658R106 | — | 8,821,067 shares | $115,026,714 |
| ZAI LAB LTD-ADR | ADR | 98887Q104 | — | 5,743,533 shares | $109,127,127 |
| ARS PHARMACEUTICALS INC | Common Stock | 82835W108 | — | 10,860,977 shares | $86,996,426 |
| XENCOR INC | Common Stock | 98401F105 | — | 5,274,274 shares | $84,915,811 |
| JADE BIOSCIENCES INC | Common Stock | 008064206 | — | 3,671,083 shares | $81,571,464 |
| INTELLIA THERAPEUTICS INC | Common Stock | 45826J105 | — | 4,526,926 shares | $76,595,588 |
| LB PHARMACEUTICALS INC | Common Stock | 50180M108 | — | 2,208,604 shares | $71,680,243 |
| DEFINIUM THERAPEUTICS INC | Common Stock | 24477V105 | — | 1,500,000 shares | $70,560,000 |
| ACLARIS THERAPEUTICS INC | Common Stock | 00461U105 | — | 12,723,026 shares | $67,304,808 |
| 4D MOLECULAR THERAPEUTICS IN | Common Stock | 35104E100 | — | 5,049,779 shares | $67,162,061 |
| SANA BIOTECHNOLOGY INC | Common Stock | 799566104 | — | 18,750,000 shares | $65,437,500 |
| DAMORA THERAPEUTICS INC | Common Stock | 36322Q206 | — | 2,399,702 shares | $62,416,249 |
| MONOPAR THERAPEUTICS INC | Common Stock | 61023L207 | — | 667,207 shares | $61,776,696 |
| ACUMEN PHARMACEUTICALS INC | Common Stock | 00509G209 | — | 20,992,669 shares | $56,050,426 |
| GERON CORP | Common Stock | 374163103 | — | 42,809,751 shares | $54,796,481 |
| REZOLUTE INC | Common Stock | 76200L309 | — | 9,445,039 shares | $49,114,203 |
| EVOMMUNE INC | Common Stock | 30054Y107 | — | 3,494,638 shares | $46,443,739 |
| VOR BIOPHARMA INC | Common Stock | 929033207 | — | 2,402,095 shares | $44,222,569 |
| CENTURY THERAPEUTICS INC | Common Stock | 15673T100 | — | 17,754,430 shares | $43,498,354 |
| AKTIS ONCOLOGY INC | Common Stock | 01021M104 | — | 1,314,405 shares | $42,363,273 |
| BIOAGE LABS INC | Common Stock | 09077V100 | — | 1,671,648 shares | $40,972,092 |
| C4 THERAPEUTICS INC | Common Stock | 12529R107 | — | 8,000,000 shares | $37,360,000 |
| MIRUM PHARMACEUTICALS INC | Common Stock | 604749101 | — | 318,554 shares | $37,293,117 |
| CAPRICOR THERAPEUTICS INC | Common Stock | 14070B309 | — | 1,507,844 shares | $36,308,884 |
| PEPGEN INC | Common Stock | 713317105 | — | 20,064,545 shares | $36,116,181 |
| PRELUDE THERAPEUTICS INC | Common Stock | 74065P101 | — | 6,475,882 shares | $34,516,451 |
| CLIMB BIO INC | Common Stock | 28658R106 | — | 2,479,872 shares | $32,337,531 |
| NKARTA INC | Common Stock | 65487U108 | — | 10,805,129 shares | $30,578,515 |
| Q32 BIO INC | Common Stock | 746964105 | — | 2,332,457 shares | $29,715,502 |
| ANTERIS TECHNOLOGIES GLOBAL | Common Stock | 03675P102 | — | 3,000,000 shares | $29,550,000 |
| EDITAS MEDICINE INC | Common Stock | 28106W103 | — | 8,889,000 shares | $28,800,360 |
| OVID THERAPEUTICS INC | Common Stock | 690469101 | — | 10,500,968 shares | $28,247,604 |
| ASSEMBLY BIOSCIENCES INC | Common Stock | 045396207 | — | 1,020,410 shares | $28,040,867 |
| ALX ONCOLOGY HOLDINGS INC | Common Stock | 00166B105 | — | 13,011,849 shares | $26,934,527 |
| BENITEC BIOPHARMA INC | Common Stock | 08205P209 | — | 1,850,000 shares | $24,753,000 |
| LENZ THERAPEUTICS INC | Common Stock | 52635N103 | — | 4,178,823 shares | $23,735,715 |
| LEXEO THERAPEUTICS INC | Common Stock | 52886X107 | — | 5,000,000 shares | $23,275,000 |
| ACRIVON THERAPEUTICS INC | Common Stock | 004890109 | — | 12,229,396 shares | $21,768,325 |
| ALTIMMUNE INC | Common Stock | 02155H200 | — | 6,500,000 shares | $19,760,000 |
| KARYOPHARM THERAPEUTICS INC | Common Stock | 48576U205 | — | 1,917,354 shares | $18,732,549 |
| BRIGHT MINDS BIOSCIENCES INC | Common Stock | 10919W405 | — | 265,000 shares | $18,603,000 |
| AVALO THERAPEUTICS INC | Common Stock | 05338F306 | — | 1,000,000 shares | $18,480,000 |
| ONKURE THERAPEUTICS INC-A | Common Stock | 68277Q105 | — | 3,998,333 shares | $18,232,398 |
| FAETH THERAPEUTICS INC | Common Stock | 81728A207 | — | 722,020 shares | $18,050,500 |
| AURA BIOSCIENCES INC | Common Stock | 05153U107 | — | 2,500,000 shares | $17,750,000 |
| SAB BIOTHERAPEUTICS INC | Common Stock | 78397T202 | — | 4,401,500 shares | $17,165,850 |
| SEAPORT THERAPEUTICS INC | Common Stock | 81221K108 | — | 700,000 shares | $15,204,000 |
| PALISADE BIO INC | Common Stock | 696389402 | — | 7,124,116 shares | $14,889,402 |
| HELIX ACQUISITION CORP-CL A | Common Stock | G4444S107 | — | 1,250,000 shares | $13,300,000 |
| WAYSTAR HOLDING CORP | Common Stock | 946784105 | — | 529,400 shares | $10,868,582 |
| EQUILLIUM INC | Common Stock | 29446K106 | — | 3,096,336 shares | $9,908,275 |
| MACROGENICS INC | Common Stock | 556099109 | — | 1,864,176 shares | $8,612,493 |
| PERCEPTIVE CAPITAL SOLUTIONS | Common Stock | G70077105 | — | 750,000 shares | $8,160,000 |
| ADICET BIO INC | Common Stock | 007002207 | — | 932,624 shares | $8,057,871 |
| NEWAMSTERDAM PHARMA CO NV-27 | WTS | N62509117 | — | 333,333 shares | $7,123,326 |
| CORVUS PHARMACEUTICALS INC | Common Stock | 221015100 | — | 450,000 shares | $6,723,000 |
| RANI THERAPEUTICS HOLDINGS-A | Common Stock | 753018100 | — | 8,500,000 shares | $6,463,400 |
| JATT II ACQUISITION CORP | Common Stock | G50765109 | — | 500,000 shares | $5,680,000 |
| AMANAT ACQUISITION CORP CL A | Common Stock | G0375M101 | — | 375,000 shares | $3,810,000 |
| WEREWOLF THERAPEUTICS INC | Common Stock | 95075A107 | — | 2,387,744 shares | $859,349 |
| PALATIN TECHNOLOGIES INC | Common Stock | 696077601 | — | 62,124 shares | $670,318 |