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RTW INVESTMENTS, LP
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $11,712,926,784
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- MADRIGAL PHARMACEUTICALS INC · COM · 558868105 · shares: $1,070,510,235
- ARGENX SE · SPONSORED ADR · 04016X101 · shares: $658,202,715
- PTC THERAPEUTICS INC · COM · 69366J200 · shares: $631,875,072
- PROTAGONIST THERAPEUTICS INC · COM · 74366E102 · shares: $620,398,832
- CG ONCOLOGY INC · COM · 156944100 · shares: $604,961,620
- INSMED INC · COM PAR $.01 · 457669307 · shares: $516,347,866
- TANGO THERAPEUTICS INC · COM · 87583X109 · shares: $434,533,381
- SPYRE THERAPEUTICS INC · COM NEW · 00773J202 · shares: $377,492,205
- CELCUITY INC · COM · 15102K100 · shares: $345,758,952
- ERASCA INC · COM · 29479A108 · shares: $328,784,533
Reported holdings
84 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | — | 1,993,687 shares | $1,070,510,235 |
| ARGENX SE | SPONSORED ADR | 04016X101 | — | 709,446 shares | $658,202,715 |
| PTC THERAPEUTICS INC | COM | 69366J200 | — | 7,746,415 shares | $631,875,072 |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | — | 5,061,175 shares | $620,398,832 |
| CG ONCOLOGY INC | COM | 156944100 | — | 8,514,590 shares | $604,961,620 |
| INSMED INC | COM PAR $.01 | 457669307 | — | 4,842,880 shares | $516,347,866 |
| TANGO THERAPEUTICS INC | COM | 87583X109 | — | 13,900,620 shares | $434,533,381 |
| SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | — | 4,251,996 shares | $377,492,205 |
| CELCUITY INC | COM | 15102K100 | — | 3,304,903 shares | $345,758,952 |
| ERASCA INC | COM | 29479A108 | — | 17,946,754 shares | $328,784,533 |
| RADNET INC | COM | 750491102 | — | 4,846,958 shares | $298,911,900 |
| ORUKA THERAPEUTICS INC | COM | 687604108 | — | 3,139,030 shares | $298,741,485 |
| NATERA INC | COM | 632307104 | — | 1,000,000 shares | $271,450,000 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | — | 7,796,895 shares | $260,338,324 |
| IRHYTHM HOLDINGS INC | COM | 450056106 | — | 2,182,631 shares | $259,623,957 |
| CYTOKINETICS INC | COM NEW | 23282W605 | — | 2,862,003 shares | $243,814,036 |
| KAILERA THERAPEUTICS INC | COMMON STOCK | 482931102 | — | 10,776,820 shares | $237,413,345 |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 | — | 2,655,695 shares | $227,885,188 |
| GUARDANT HEALTH INC | COM | 40131M109 | — | 1,481,033 shares | $222,199,381 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | — | 1,267,925 shares | $213,689,740 |
| TARSUS PHARMACEUTICALS INC | COM | 87650L103 | — | 3,357,059 shares | $211,293,293 |
| STOKE THERAPEUTICS INC | COM | 86150R107 | — | 5,623,525 shares | $184,001,738 |
| UNIQURE NV | SHS | N90064101 | — | 3,941,572 shares | $181,548,806 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | — | 7,144,524 shares | $180,756,457 |
| REPLIGEN CORP | COM | 759916109 | — | 1,240,637 shares | $169,272,512 |
| UROGEN PHARMA LTD | COM | M96088105 | — | 4,543,895 shares | $167,215,336 |
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | — | 5,933,815 shares | $159,500,947 |
| IMMUNOCORE HLDGS PLC | ADS | 45258D105 | — | 4,869,798 shares | $154,616,087 |
| COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | — | 10,700,974 shares | $151,418,782 |
| IMMATICS N.V | SHS | N44445109 | — | 12,946,176 shares | $131,144,763 |
| ZAI LAB LTD | ADR | 98887Q104 | — | 6,574,032 shares | $124,906,608 |
| IMMUNOVANT INC | COM | 45258J102 | — | 3,177,849 shares | $122,442,522 |
| BELITE BIO INC | SPONSORED ADS | 07782B104 | — | 715,332 shares | $110,150,398 |
| XENCOR INC | COM | 98401F105 | — | 6,777,461 shares | $109,117,122 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | — | 13,560,258 shares | $92,345,357 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | — | 2,309,021 shares | $89,359,113 |
| ALKERMES PLC | SHS | G01767105 | — | 1,672,356 shares | $87,623,093 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | — | 1,607,507 shares | $86,274,901 |
| REPLIMUNE GROUP INC | COM | 76029N106 | — | 7,411,581 shares | $82,046,202 |
| CASTLE BIOSCIENCES INC | COM | 14843C105 | — | 2,778,335 shares | $66,263,290 |
| CANDEL THERAPEUTICS INC | COM | 137404109 | — | 6,422,018 shares | $66,146,785 |
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | — | 17,687,772 shares | $60,492,180 |
| KODIAK SCIENCES INC | COM | 50015M109 | — | 1,487,934 shares | $57,969,909 |
| AKTIS ONCOLOGY INC | COM | 01021M104 | — | 1,592,043 shares | $51,311,546 |
| AXOGEN INC | COM | 05463X106 | — | 1,011,576 shares | $46,724,695 |
| DANAHER CORP DEL | COM | 235851102 | — | 230,000 shares | $43,810,400 |
| CULLINAN THERAPEUTICS INC | COM | 230031106 | — | 2,364,347 shares | $43,054,759 |
| NEUROGENE INC | COM | 64135M105 | — | 1,362,456 shares | $42,849,241 |
| HINGE HEALTH INC | CL A | 433313103 | — | 500,000 shares | $41,500,000 |
| ORCHESTRA BIOMED HLDGS INC | COM | 68572M106 | — | 9,556,063 shares | $41,234,412 |
| SOLID BIOSCIENCES INC | COM NEW | 83422E204 | — | 3,892,926 shares | $38,890,331 |
| SAVARA INC | COM | 805111101 | — | 5,952,380 shares | $36,666,661 |
| AQUESTIVE THERAPEUTICS INC | COM | 03843E104 | — | 7,426,471 shares | $30,894,119 |
| KYMERA THERAPEUTICS INC | COM | 501575104 | — | 240,000 shares | $27,520,800 |
| VERASTEM INC | COM NEW | 92337C203 | — | 6,635,793 shares | $25,348,729 |
| DIANTHUS THERAPEUTICS INC | COM | 252828108 | — | 248,063 shares | $24,181,181 |
| BETA BIONICS INC | COM | 08659B102 | — | 1,500,000 shares | $23,505,000 |
| CENTURY THERAPEUTICS INC | COM | 15673T100 | — | 8,695,652 shares | $21,304,347 |
| EVOMMUNE INC | COM SHS | 30054Y107 | — | 1,502,235 shares | $19,964,703 |
| BEAM THERAPEUTICS INC | COM | 07373V105 | — | 570,394 shares | $19,575,922 |
| DEFINIUM THERAPEUTICS INC | COM SHS | 24477V105 | — | 400,000 shares | $18,816,000 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | — | 370,370 shares | $13,803,690 |
| ATAIBECKLEY INC | COM SHS | 04650F101 | — | 2,000,000 shares | $10,540,000 |
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | — | 7,833,336 shares | $10,496,670 |
| OCUGEN INC | COM | 67577C105 | — | 6,666,666 shares | $10,199,999 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 | — | 696,570 shares | $10,135,094 |
| HEARTFLOW INC | COM | 42238D107 | — | 295,000 shares | $8,655,300 |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 | — | 742,500 shares | $8,078,400 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | — | 1,350,000 shares | $7,843,500 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 | — | 2,565,999 shares | $7,826,297 |
| LUMEXA IMAGING HOLDINGS INC | COM | 550249106 | — | 650,000 shares | $7,332,000 |
| ALLOGENE THERAPEUTICS INC | COM | 019770106 | — | 3,250,000 shares | $6,760,000 |
| CRESCENT BIOPHARMA INC. | COM | G2545C104 | — | 372,856 shares | $6,711,408 |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | — | 475,737 shares | $6,327,302 |
| MAZE THERAPEUTICS INC | COM | 578784100 | — | 212,000 shares | $6,326,080 |
| CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | — | 250,000 shares | $6,020,000 |
| KALARIS THERAPEUTICS INC | COM | 482929106 | — | 1,300,000 shares | $5,291,000 |
| ABIVAX SA | SPONSORED ADS | 00370M103 | — | 26,400 shares | $3,518,064 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 | — | 175,000 shares | $3,234,000 |
| MEDLINE INC | COM CL A | 58507V107 | — | 70,000 shares | $2,760,800 |
| DISC MEDICINE INC | COM | 254604101 | — | 30,000 shares | $2,194,200 |
| IMAGENEBIO INC | COM | 45175G207 | — | 334,445 shares | $1,973,226 |
| EXAGEN INC | COM | 30068X103 | — | 195,000 shares | $906,750 |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | 77313F114 | — | 350,000 shares | $1,190 |