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SPHERA FUNDS MANAGEMENT LTD.
Period ended Jun 30, 2026 · Latest filing Aug 14, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Jun 30, 2026: $766,539,858
More quarters will appear as history becomes available.
Top holdings
Top 10 at Jun 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- TEVA PHARMACEUTICAL INDS LTD · SPONSORED ADS · 881624209 · shares: $50,822,778
- MINERALYS THERAPEUTICS INC · COM · 603170101 · shares: $39,659,818
- TOWER SEMICONDUCTOR LTD · SHS NEW · M87915274 · shares: $28,218,190
- SPDR SERIES TRUST · ST STR SP BIOT · 78464A870 · shares · PUT: $23,737,500
- SYNDAX PHARMACEUTICALS INC · COM · 87164F105 · shares: $22,179,287
- BIOGEN INC · COM · 09062X103 · shares · CALL: $21,606,000
- BIOGEN INC · COM · 09062X103 · shares: $20,877,014
- ULTRAGENYX PHARMACEUTICAL IN · COM · 90400D108 · shares: $19,649,815
- BIOMARIN PHARMACEUTICAL INC · COM · 09061G101 · shares: $18,799,631
- CYTOKINETICS INC · COM NEW · 23282W605 · shares: $18,740,693
Reported holdings
106 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | — | 1,410,082 shares | $47,773,578 |
| MINERALYS THERAPEUTICS INC | COM | 603170101 | — | 1,469,971 shares | $39,659,818 |
| TOWER SEMICONDUCTOR LTD | SHS NEW | M87915274 | — | 108,265 shares | $28,218,190 |
| SPDR SERIES TRUST | ST STR SP BIOT | 78464A870 | PUT | 150,000 shares | $23,737,500 |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | — | 1,014,606 shares | $22,179,287 |
| BIOGEN INC | COM | 09062X103 | CALL | 100,000 shares | $21,606,000 |
| BIOGEN INC | COM | 09062X103 | — | 96,626 shares | $20,877,014 |
| ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | — | 588,494 shares | $19,649,815 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | — | 328,550 shares | $18,799,631 |
| CYTOKINETICS INC | COM NEW | 23282W605 | — | 219,987 shares | $18,740,693 |
| BRIDGEBIO PHARMA INC | COM | 10806X102 | — | 245,346 shares | $18,273,370 |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | — | 459,340 shares | $17,776,458 |
| NOVA LTD | COM | M7516K103 | — | 25,169 shares | $13,665,257 |
| INSMED INC | COM PAR $.01 | 457669307 | — | 118,800 shares | $12,666,456 |
| MAZE THERAPEUTICS INC | COM | 578784100 | — | 417,564 shares | $12,460,110 |
| ASTRAZENECA PLC | ORD | G0593M107 | — | 62,530 shares | $11,856,939 |
| SANOFI SA | SPONSORED ADR | 80105N105 | — | 269,515 shares | $11,497,510 |
| CYBIN INC | COM NEW | 23256X407 | — | 1,620,753 shares | $10,713,177 |
| ELI LILLY & CO | COM | 532457108 | — | 8,040 shares | $9,643,417 |
| MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | — | 17,419 shares | $9,353,132 |
| TREVI THERAPEUTICS INC | COM | 89532M101 | — | 499,029 shares | $9,306,891 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | — | 356,534 shares | $9,020,310 |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | — | 240,868 shares | $8,962,698 |
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | — | 80,400 shares | $8,926,812 |
| CYTOKINETICS INC | COM NEW | 23282W605 | CALL | 100,000 shares | $8,519,000 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 | — | 752,983 shares | $8,154,806 |
| LAM RESEARCH CORP | COM NEW | 512807306 | — | 18,470 shares | $8,003,605 |
| APPLIED MATLS INC | COM | 038222105 | — | 11,040 shares | $7,981,920 |
| TANGO THERAPEUTICS INC | COM | 87583X109 | — | 254,250 shares | $7,947,855 |
| NOVARTIS AG | SPONSORED ADR | 66987V109 | — | 50,000 shares | $7,832,904 |
| SOLAREDGE TECHNOLOGIES INC | NOTE 2.250% 7/0 | 83417MAE4 | — | 4,000,000 shares | $7,747,190 |
| VOR BIOPHARMA INC | COM NEW | 929033207 | — | 416,417 shares | $7,666,237 |
| ABBVIE INC | COM | 00287Y109 | — | 30,256 shares | $7,613,620 |
| MERCK & CO INC | COM | 58933Y105 | — | 58,600 shares | $7,530,100 |
| JOHNSON & JOHNSON | COM | 478160104 | — | 28,831 shares | $7,322,209 |
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | — | 196,408 shares | $7,320,126 |
| IMMATICS N.V | SHS | N44445109 | — | 720,057 shares | $7,294,177 |
| NUVECTIS PHARMA INC | COM | 67080T108 | — | 382,945 shares | $7,042,359 |
| PFIZER INC | COM | 717081103 | — | 286,000 shares | $6,886,880 |
| HARMONY BIOSCIENCES HLDGS IN | COM | 413197104 | — | 176,663 shares | $6,432,300 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | — | 105,000 shares | $6,337,800 |
| CLIMB BIO INC | COM | 28658R106 | — | 483,747 shares | $6,308,061 |
| ZENAS BIOPHARMA INC | COM | 98937L105 | — | 230,834 shares | $5,858,567 |
| NOVO-NORDISK A S | ADR | 670100205 | — | 120,677 shares | $5,785,255 |
| ENLIVEN THERAPEUTICS INC | COM | 29337E102 | — | 112,765 shares | $5,722,824 |
| PRELUDE THERAPEUTICS INC | COM | 74065P101 | — | 1,019,832 shares | $5,435,705 |
| GSK PLC | SPONSORED ADR | 37733W204 | — | 102,000 shares | $5,346,840 |
| FORTE BIOSCIENCES INC | COM NEW | 34962G208 | — | 249,693 shares | $5,305,976 |
| BIOAGE LABS INC | COM | 09077V100 | — | 213,671 shares | $5,237,076 |
| SCHOLAR ROCK HLDG CORP | COM | 80706P103 | — | 94,265 shares | $5,184,575 |
| SATELLOS BIOSCIENCE INC | COM | 80401L803 | — | 652,590 shares | $5,073,887 |
| PALISADE BIO INC | COM | 696389402 | — | 2,257,106 shares | $4,717,352 |
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | — | 1,191,187 shares | $4,693,277 |
| VISTRA CORP | COM | 92840M102 | — | 29,450 shares | $4,671,654 |
| TALEN ENERGY CORP | COM | 87422Q109 | — | 12,135 shares | $4,662,995 |
| SAVARA INC | COM | 805111101 | — | 756,164 shares | $4,657,970 |
| DISC MEDICINE INC | COM | 254604101 | — | 63,538 shares | $4,647,169 |
| GLOBAL X FDS | CLOUD COMPUTNG | 37954Y442 | — | 195,900 shares | $4,454,766 |
| DYNE THERAPEUTICS INC | COM | 26818M108 | — | 199,594 shares | $4,432,983 |
| RELAY THERAPEUTICS INC | COM | 75943R102 | — | 233,836 shares | $4,375,072 |
| AVALO THERAPEUTICS INC | COM NEW | 05338F306 | — | 232,294 shares | $4,292,793 |
| PROMIS NEUROSCIENCES INC | COM SHS | 74346M505 | — | 325,591 shares | $4,284,784 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | — | 422,051 shares | $4,220,510 |
| REVOLUTION MEDICINES INC | COM | 76155X100 | — | 22,400 shares | $4,195,072 |
| PRAXIS PRECISION MEDICINES I | COM NEW | 74006W207 | CALL | 12,500 shares | $4,184,875 |
| CABALETTA BIO INC | COM | 12674W109 | — | 1,329,012 shares | $4,133,227 |
| GENERATE BIOMEDICINES INC | COM SHS | 370920100 | — | 245,000 shares | $4,133,150 |
| ISHARES TR | 20 YR TR BD ETF | 464287432 | CALL | 47,000 shares | $4,061,740 |
| MEDIWOUND LTD | SHS NEW | M68830112 | — | 273,192 shares | $4,015,922 |
| ALPHA COGNITION INC | COM NEW | 02074J501 | — | 545,816 shares | $3,940,792 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | — | 638,272 shares | $3,708,360 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | — | 244,961 shares | $3,659,717 |
| OVID THERAPEUTICS INC | COM | 690469101 | — | 1,353,000 shares | $3,639,570 |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | 107924102 | — | 460,985 shares | $3,512,706 |
| CYTOMX THERAPEUTICS INC. | COM | 23284F105 | — | 879,000 shares | $3,296,250 |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 | — | 1,757,458 shares | $3,268,872 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | — | 10,800 shares | $3,251,124 |
| KURA ONCOLOGY INC | COM | 50127T109 | — | 295,039 shares | $3,236,578 |
| KODIAK SCIENCES INC | COM | 50015M109 | — | 81,796 shares | $3,186,772 |
| ORMAT TECHNOLOGIES INC | COM | 686688102 | — | 28,015 shares | $3,050,834 |
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | — | 90,000 shares | $3,049,200 |
| CONTINEUM THERAPEUTICS INC | CL A | 21217B100 | — | 183,475 shares | $3,007,155 |
| LARIMAR THERAPEUTICS INC | COM | 517125100 | — | 926,004 shares | $2,824,312 |
| IMMIX BIOPHARMA INC | COM | 45258H106 | — | 270,000 shares | $2,783,700 |
| AMGEN INC | COM | 031162100 | — | 7,500 shares | $2,715,900 |
| ABIVAX SA | SPONSORED ADS | 00370M103 | PUT | 20,000 shares | $2,665,200 |
| BIOHAVEN LTD | COM | G1110E107 | — | 164,437 shares | $2,446,823 |
| CONSTELLATION ENERGY CORP | COM | 21037T109 | — | 9,850 shares | $2,446,445 |
| VERASTEM INC | COM NEW | 92337C203 | — | 632,632 shares | $2,416,654 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 | CALL | 127,600 shares | $1,856,580 |
| TENAX THERAPEUTICS INC | COM NEW | 88032L605 | — | 120,200 shares | $1,748,910 |
| TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | — | 250,000 shares | $1,702,500 |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | — | 28,600 shares | $1,534,962 |
| UPSTREAM BIO INC | COM | 91678A107 | — | 219,700 shares | $1,520,324 |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | — | 427,554 shares | $1,496,439 |
| ORGANOGENESIS HLDGS INC | COM | 68621F102 | — | 550,000 shares | $1,336,500 |
| INHIBIKASE THERAPEUTICS INC | COM NEW | 45719W205 | — | 649,309 shares | $1,318,097 |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 | CALL | 100,000 shares | $1,083,000 |
| CURIS INC | COM | 231269309 | — | 98,996 shares | $1,033,717 |
| SHATTUCK LABS INC | COM | 82024L103 | — | 86,461 shares | $600,039 |