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Siren, L.L.C.
Period ended Sep 30, 2026 · Latest filing Nov 12, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Sep 30, 2026: $4,231,656,130
More quarters will appear as history becomes available.
Top holdings
Top 10 at Sep 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- Scholar Rock Holding Corporation · COM · 80706P103 · shares: $453,000,628
- Kymera Therapeutics, Inc. · COM · 501575104 · shares: $311,323,747
- Erasca, Inc. · COM · 29479A108 · shares: $193,479,469
- Revolution Medicines, Inc. · COM · 76155X100 · shares: $174,471,000
- BeOne Medicines AG · SPONSORED ADS · 07725L102 · shares: $170,162,100
- Tango Therapeutics, Inc. · COM · 87583X109 · shares: $169,262,821
- Veradermics, Incorporated · COMMON STOCK · 922967104 · shares: $160,544,768
- Arrowhead Pharmaceuticals, Inc. · COM · 04280A100 · shares: $149,911,654
- Edgewise Therapeutics, Inc. · COM · 28036F105 · shares: $113,849,667
- Rhythm Pharmaceuticals, Inc. · COM · 76243J105 · shares: $103,429,674
Reported holdings
113 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| Scholar Rock Holding Corporation | COM | 80706P103 | — | 9,375,013 shares | $453,000,628 |
| Kymera Therapeutics, Inc. | COM | 501575104 | — | 2,784,898 shares | $311,323,747 |
| Erasca, Inc. | COM | 29479A108 | — | 13,197,781 shares | $193,479,469 |
| Revolution Medicines, Inc. | COM | 76155X100 | — | 850,000 shares | $174,471,000 |
| BeOne Medicines AG | SPONSORED ADS | 07725L102 | — | 465,000 shares | $170,162,100 |
| Tango Therapeutics, Inc. | COM | 87583X109 | — | 6,784,081 shares | $169,262,821 |
| Veradermics, Incorporated | COMMON STOCK | 922967104 | — | 1,324,299 shares | $160,544,768 |
| Arrowhead Pharmaceuticals, Inc. | COM | 04280A100 | — | 2,290,476 shares | $149,911,654 |
| Edgewise Therapeutics, Inc. | COM | 28036F105 | — | 2,804,179 shares | $113,849,667 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | — | 1,086,275 shares | $103,429,674 |
| Bicara Therapeutics Inc | COM | 055477103 | — | 5,502,970 shares | $102,410,272 |
| Parabilis Medicines Inc | COM | 698955101 | — | 2,992,259 shares | $96,620,043 |
| Lexicon Pharmaceuticals, Inc. | COM NEW | 528872302 | — | 44,303,518 shares | $83,290,614 |
| Spyre Therapeutics Inc | COM NEW | 00773J202 | — | 868,598 shares | $77,331,280 |
| Tyra Biosciences, Inc. | COM | 90240B106 | — | 3,395,887 shares | $74,268,049 |
| Hemab Therapeutics Holdings Inc | COM SHS | 423494103 | — | 2,366,235 shares | $72,974,687 |
| Amylyx Pharmaceuticals, Inc. | COM | 03237H101 | — | 2,480,586 shares | $72,185,053 |
| Enliven Therapeutics, Inc. | COM | 29337E102 | — | 1,475,163 shares | $67,621,472 |
| Septerna, Inc. | COM | 81734D104 | — | 1,700,000 shares | $66,521,000 |
| Relay Therapeutics, Inc. | COM | 75943R102 | — | 3,262,976 shares | $58,896,717 |
| Disc Medicine, Inc. | COM | 254604101 | — | 888,401 shares | $58,154,729 |
| Solid Biosciences Inc | COM NEW | 83422E204 | — | 7,690,405 shares | $55,601,628 |
| Stoke Therapeutics, Inc. | COM | 86150R107 | — | 1,995,347 shares | $51,879,022 |
| Cogent Biosciences, Inc. | COM | 19240Q201 | — | 1,609,279 shares | $51,529,114 |
| Taysha Gene Therapies, Inc. | COM SHS | 877619106 | — | 9,846,579 shares | $47,952,840 |
| Cytokinetics, Incorporated | COM NEW | 23282W605 | — | 708,952 shares | $46,727,026 |
| Arcus Biosciences, Inc. | COM | 03969F109 | — | 1,745,000 shares | $45,073,350 |
| Olema Pharmaceuticals, Inc. | COM | 68062P106 | — | 4,856,949 shares | $41,964,039 |
| Dyne Therapeutics, Inc. | COM | 26818M108 | — | 2,429,125 shares | $39,133,204 |
| ADARx Pharmaceuticals, Inc. | COM | 00654F105 | — | 1,925,794 shares | $38,400,332 |
| Remitly Global Inc | COM | 75960P104 | — | 1,543,271 shares | $32,933,403 |
| ORIC Pharmaceuticals, Inc. | COM | 68622P109 | — | 2,350,617 shares | $31,662,811 |
| Silence Therapeutics PLC | ADS | 82686Q101 | — | 2,887,867 shares | $31,564,386 |
| Ascendis Pharma A/S | ORD SHS | K08588103 | — | 130,000 shares | $29,617,900 |
| Denali Therapeutics Inc. | COM | 24823R105 | — | 1,396,513 shares | $28,865,924 |
| Palvella Therapeutics Inc | COM | 697947109 | — | 207,485 shares | $28,618,406 |
| Dbv Technologies SA | SPONSORED ADS | 23306J309 | — | 2,356,539 shares | $27,712,899 |
| Cullinan Therapeutics, Inc. | COM | 230031106 | — | 1,793,410 shares | $27,528,844 |
| Alphabet Inc. | CAP STK CL A | 02079K305 | — | 80,000 shares | $27,526,400 |
| Structure Therapeutics Inc. | SPONSORED ADS | 86366E106 | — | 872,967 shares | $27,297,678 |
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | — | 718,306 shares | $26,713,800 |
| Kailera Therapeutics Inc | COMMON STOCK | 482931102 | — | 2,214,286 shares | $25,287,146 |
| Agenus Inc | COM NEW | 00847G804 | — | 2,419,263 shares | $24,023,282 |
| NVIDIA Corporation | COM | 67066G104 | — | 97,500 shares | $22,267,050 |
| Seaport Therapeutics Inc | COMMON STOCK | 81221K108 | — | 1,095,316 shares | $22,092,524 |
| Trevi Therapeutics, Inc. | COM | 89532M101 | — | 1,523,889 shares | $21,822,090 |
| Rapport Therapeutics, Inc. | COM | 75383L102 | — | 641,469 shares | $21,553,358 |
| Monopar Therapeutics Inc. | COM NEW | 61023L207 | — | 270,118 shares | $21,520,301 |
| Taiwan Semiconductor Manufacturing Company Limited | SPONSORED ADS | 874039100 | — | 45,000 shares | $20,528,550 |
| Damora Therapeutics Inc | COM SHS | G2646Y104 | — | 900,000 shares | $19,152,000 |
| Abivax SA | SPONSORED ADS | 00370M103 | — | 188,000 shares | $18,615,760 |
| Annexon, Inc. | COM | 03589W102 | — | 4,359,560 shares | $18,440,939 |
| Entera Bio Ltd | SHS | M40527109 | — | 6,000,000 shares | $17,460,000 |
| Arcus Biosciences, Inc. | COM | 03969F109 | — | 675,430 shares | $17,446,357 |
| Microsoft Corporation | COM | 594918104 | — | 34,000 shares | $17,438,600 |
| Zura Bio Ltd | CLASS A ORD SHS | G9TY5A101 | — | 3,734,866 shares | $15,537,043 |
| Yarrow Bioscience, Inc. | COM | 92941V407 | — | 675,000 shares | $15,201,000 |
| Absci Corp | COM | 00091E109 | — | 1,374,764 shares | $14,806,208 |
| SK hynix Inc. | AMERICAN DEPOSIT | 78392B206 | — | 80,000 shares | $14,732,000 |
| Taboola.com Ltd | ORD SHS | M8744T106 | — | 4,259,868 shares | $14,313,156 |
| GH Research PLC | ORDINARY SHARES | G3855L106 | — | 600,000 shares | $14,088,000 |
| Rezolute, Inc. | COM NEW | 76200L309 | — | 3,328,287 shares | $13,779,108 |
| ORIC Pharmaceuticals, Inc. | COM | 68622P109 | — | 1,007,575 shares | $13,572,035 |
| enGene Therapeutics Inc. | COM | 29286X101 | — | 6,256,662 shares | $12,513,324 |
| Microsoft Corporation | COM | 594918104 | CALL | 24,000 shares | $12,309,600 |
| ServiceNow, Inc. | COM | 81762P102 | — | 90,000 shares | $12,060,900 |
| Inhibikase Therapeutics, Inc. | COM NEW | 45719W205 | — | 5,850,000 shares | $12,021,750 |
| Nebius Group NV | SHS CLASS A | N97284108 | — | 47,500 shares | $11,204,300 |
| Generate Biomedicines Inc | COM SHS | 370920100 | — | 736,104 shares | $11,056,282 |
| Dynatrace, Inc | COM NEW | 268150109 | — | 190,000 shares | $10,970,600 |
| Aclaris Therapeutics, Inc. | COM | 00461U105 | — | 2,025,000 shares | $10,651,500 |
| Broadcom Inc | COM | 11135F101 | — | 29,500 shares | $10,360,105 |
| CytomX Therapeutics, Inc. | COM | 23284F105 | — | 3,457,711 shares | $9,404,974 |
| Whitehawk Therapeutics, Inc. | COM | 00032Q104 | — | 2,337,102 shares | $8,787,504 |
| Satellos Bioscience Inc. | COM | 80401L803 | — | 892,074 shares | $7,582,629 |
| IONQ Inc | COM | 46222L108 | — | 170,000 shares | $7,456,200 |
| Design Therapeutics, Inc. | COM | 25056L103 | — | 523,212 shares | $6,576,775 |
| JFrog Ltd. | ORD SHS | M6191J100 | — | 66,500 shares | $6,453,160 |
| Eloxx Pharmaceuticals Inc | COM NEW | 29014R301 | — | 400,000 shares | $6,124,000 |
| Oculis Holding AG | ORDINARY SHARES | H5870P102 | — | 625,000 shares | $5,837,500 |
| Crescent Biopharma, Inc. | COM | G2545C104 | — | 400,000 shares | $5,836,000 |
| Amazon.com Inc | COM | 023135106 | — | 21,500 shares | $5,356,725 |
| CrowdStrike Holdings, Inc. | CL A | 22788C105 | — | 20,000 shares | $5,295,000 |
| Neumora Therapeutics Inc | COM | 640979100 | — | 8,497,822 shares | $5,066,401 |
| vTv Therapeutics Inc | CL A NEW | 918385204 | — | 163,000 shares | $5,026,920 |
| Datadog Inc | CL A COM | 23804L103 | — | 18,000 shares | $4,929,300 |
| Agomab Therapeutics NV | SPONSORED ADS | 00860C102 | — | 411,250 shares | $4,564,875 |
| Odyssey Therapeutics Inc | COMMON STOCK | 67613T104 | — | 200,000 shares | $4,444,000 |
| Invivyd, Inc. | COM | 00534A102 | — | 5,000,000 shares | $4,350,500 |
| Jersey Mike's Subs Inc | COM SHS CL A | 47668J102 | — | 250,000 shares | $4,205,000 |
| IREN Limited | ORDINARY SHARES | Q4982L109 | — | 100,000 shares | $4,088,000 |
| Ouster, Inc. | COM NEW | 68989M202 | — | 100,000 shares | $4,034,000 |
| Wise Group PLC | ORD SHS CLASS A | G9723Y105 | — | 350,906 shares | $4,022,368 |
| TTM Technologies Inc | COM | 87305R109 | — | 30,000 shares | $3,685,200 |
| Korro Bio, Inc. | COM | 500946108 | — | 347,718 shares | $3,445,885 |
| monday.com Ltd. | SHS | M7S64H106 | — | 37,500 shares | $2,942,250 |
| Aeva Technologies, Inc. | COM NEW | 00835Q202 | — | 200,000 shares | $2,808,000 |
| Amer Sports Inc | COM SHS | G0260P102 | — | 100,000 shares | $2,729,000 |
| Palisade Bio Inc | COM | 696389402 | — | 2,000,000 shares | $2,700,000 |
| Foghorn Therapeutics Inc. | COM | 344174107 | — | 720,720 shares | $2,572,970 |