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Siren, L.L.C.
Period ended Sep 30, 2026 · Latest filing Nov 12, 2026
These quarterly holdings are delayed and may not include all assets or short positions.
Values are from the reporting date, not current prices or purchase costs.
The same security may appear in multiple rows.
Source: SEC
Reported portfolio value
Quarter-end reported holdings; not current value or investment performance.
View reported values
- Sep 30, 2026: $4,231,656,130
More quarters will appear as history becomes available.
Top holdings
Top 10 at Sep 30, 2026. Matching entries are combined; security classes and options remain separate. Shares exclude principal amounts; option shares reflect the reported underlying amount.
View top holdings values
- Scholar Rock Holding Corporation · COM · 80706P103 · shares: $453,000,628
- Kymera Therapeutics, Inc. · COM · 501575104 · shares: $311,323,747
- Erasca, Inc. · COM · 29479A108 · shares: $193,479,469
- Revolution Medicines, Inc. · COM · 76155X100 · shares: $174,471,000
- BeOne Medicines AG · SPONSORED ADS · 07725L102 · shares: $170,162,100
- Tango Therapeutics, Inc. · COM · 87583X109 · shares: $169,262,821
- Veradermics, Incorporated · COMMON STOCK · 922967104 · shares: $160,544,768
- Arrowhead Pharmaceuticals, Inc. · COM · 04280A100 · shares: $149,911,654
- Edgewise Therapeutics, Inc. · COM · 28036F105 · shares: $113,849,667
- Rhythm Pharmaceuticals, Inc. · COM · 76243J105 · shares: $103,429,674
Reported holdings
113 reported entries| Issuer | Class | CUSIP | Type | Shares / principal | Reported value (USD) |
|---|---|---|---|---|---|
| GitLab Inc. | CLASS A COM | 37637K108 | — | 50,000 shares | $2,362,500 |
| Bank of America Corporation | COM | 060505104 | — | 40,000 shares | $2,177,200 |
| The Charles Schwab Corporation | COM | 808513105 | — | 15,000 shares | $1,466,100 |
| Diamondback Energy, Inc. | COM | 25278X109 | — | 7,500 shares | $1,378,575 |
| Adagene Inc. | ADS | 005329107 | — | 421,658 shares | $1,349,306 |
| MGM Resorts International | COM | 552953101 | — | 43,000 shares | $1,335,150 |
| Rani Therapeutics Holdings Inc | COM CL A | 753018100 | — | 1,594,800 shares | $1,261,487 |
| Figma, Inc. | CLASS A COM STK | 316841105 | — | 50,000 shares | $1,051,000 |
| Kalaris Therapeutics Inc | COM | 482929106 | — | 356,559 shares | $1,030,456 |
| Quantinuum Inc | CL A COM | 74768A104 | — | 20,000 shares | $961,200 |
| Zoetis Inc | CL A | 98978V103 | — | 12,500 shares | $872,875 |
| Gossamer Bio, Inc. | COM | 38341P201 | — | 65,112 shares | $771,577 |
| Primo Brands Corp | CLASS A COM SHS | 741623102 | — | 25,000 shares | $476,250 |